DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF OFLOXACIN AND ORNIDAZOLE IN PRESENCE OF ORNIDAZOLE IMPURITY IN COMBINED PHARMACEUTICAL DOSAGE FORM
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چکیده
منابع مشابه
Simultaneous Determination of Ofloxacin and Ornidazole in Solid Dosage Form by RP-HPLC and HPTLC Techniques
The objective of this work was to develop and validate simple, rapid and accurate chromatographic methods for simultaneous determination of ofloxacin and ornidazole in solid dosage form. The first method was based on reversed phase high performance liquid chromatography, on Intersil C(18) column (250 mm, 4.6 i.d.), using acetonitrile:methanol: 0.025M phosphate buffer, pH 3.0 (30:10:60 % v/v/v) ...
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متن کاملDevelopment and Validation of RP-HPLC method for simultaneous estimation of Methyldopa and Hydrochlorothiazide in Pharmaceutical Dosage Form
INTORDUCTION Methyldopa is (2S)-2-amino-3-(3, 4dihydroxyphenyl)-2-methylpropanoic acid (figure1a). Hydrochlorothiazide is 6-chloro-1, 1-dioxo-3,4dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide (figure1b). Methyldopa and Hydrochlorothiazide are official in Indian Pharmacopoeia and U.S. Pharmacopoeia, but there is no official method for the combination. Both drugs in combination of tablet dosage ...
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ژورنال
عنوان ژورنال: World Journal of Pharmaceutical Research
سال: 2017
ISSN: 2277-7105
DOI: 10.20959/wjpr20179-9213